Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden

Chemotherapy resistance associated with recurrent disease is the major cause of poor survival of ovarian cancer patients. We have recently demonstrated activation of the JAK2/STAT3 pathway and the enhancement of a cancer stem cell (CSC)-like phenotype in ovarian cancer cells treated in vitro with ch...

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Detalhes bibliográficos
Main Authors: Abubaker, Khalid, Luwor, Rodney B., Escalona, Ruth, McNally, Orla, Quinn, Michael A., Thompson, Erik W., Findlay, Jock K., Ahmed, Nuzhat
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988380/
https://ncbi.nlm.nih.gov/pubmed/24782986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00075
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