Distinct and Overlapping Functions of ptpn11 Genes in Zebrafish Development

The PTPN11 (protein-tyrosine phosphatase, non-receptor type 11) gene encodes SHP2, a cytoplasmic PTP that is essential for vertebrate development. Mutations in PTPN11 are associated with Noonan and LEOPARD syndrome. Human patients with these autosomal dominant disorders display various symptoms, inc...

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Autors principals: Bonetti, Monica, Rodriguez-Martinez, Virginia, Paardekooper Overman, Jeroen, Overvoorde, John, van Eekelen, Mark, Jopling, Chris, den Hertog, Jeroen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988099/
https://ncbi.nlm.nih.gov/pubmed/24736444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094884
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