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Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting

Three-dimensional (3D) tissue culture models may recapitulate aspects of the tumorigenic microenvironment in vivo, enabling the study of cancer progression in vitro. Both hypoxia and matrix stiffness are known to regulate tumor growth. Using a modular culture system employing an acrylated hyaluronic...

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Detalhes bibliográficos
Main Authors: Shen, Yu-I, Abaci, Hasan E., Krupsi, Yoni, Weng, Lien-Chun, Burdick, Jason A., Gerecht, Sharon
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987918/
https://ncbi.nlm.nih.gov/pubmed/24748963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3BM60274E
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