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ENU-induced mutation in USP18 causes hyperactivation of IFN-αβ signalling and suppresses STAT4-induced IFN-γ production resulting in increased susceptibility to Salmonella Typhimurium
In order to deepen our knowledge of the natural host response to pathogens our team undertook an in vivo screen of mutagenized 129S1 mice with Salmonella Typhimurium. One mutation affecting Salmonella susceptibility was mapped to a region of 1.3Mb on chromosome 6 that contains 15 protein-coding gene...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3987673/ https://ncbi.nlm.nih.gov/pubmed/20693420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000890 |
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