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Deoxyglucose prevents neurodegeneration in culture by eliminating microglia

BACKGROUND: 2-Deoxy-d-glucose is an inhibitor of glycolysis, which is protective in animal models of brain pathology, but the mechanisms of this protection are unclear. We examined whether, when and how deoxyglucose protects neurons in co-culture with astrocytes and microglia. Microglia are brain ma...

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Hlavní autoři: Vilalta, Anna, Brown, Guy C
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986974/
https://ncbi.nlm.nih.gov/pubmed/24669778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-58
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