Effects of cytosine methylation on transcription factor binding sites

BACKGROUND: DNA methylation in promoters is closely linked to downstream gene repression. However, whether DNA methylation is a cause or a consequence of gene repression remains an open question. If it is a cause, then DNA methylation may affect the affinity of transcription factors (TFs) for their...

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Autori principali: Medvedeva, Yulia A, Khamis, Abdullah M, Kulakovskiy, Ivan V, Ba-Alawi, Wail, Bhuyan, Md Shariful I, Kawaji, Hideya, Lassmann, Timo, Harbers, Matthias, Forrest, Alistair RR, Bajic, Vladimir B
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986887/
https://ncbi.nlm.nih.gov/pubmed/24669864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-119
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