Gene silencing of β-galactosamide α-2,6-sialyltransferase 1 inhibits human influenza virus infection of airway epithelial cells

BACKGROUND: Human influenza virus hemagglutinin prefers to use sialic acid (SA) receptors via α-2,6 linkages. The β-galactoside α-2,6-sialyltransferase I (ST6Gal I) protein is encoded by the ST6GAL1 gene and is responsible for the addition of α-2,6 linked SA to the Galβ1-4GlcNAc disaccharide of glyc...

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Hauptverfasser: Wu, Dong, Huang, Wenbo, Wang, Yutao, Guan, Wenda, Li, Runfeng, Yang, Zifeng, Zhong, Nanshan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986885/
https://ncbi.nlm.nih.gov/pubmed/24670114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-14-78
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