Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function

Duchenne muscular dystrophy in boys progresses rapidly to severe impairment of muscle function and death in the second or third decade of life. Current supportive therapy with corticosteroids results in a modest increase in strength as a consequence of a general reduction in inflammation, albeit wit...

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Bibliografiske detaljer
Main Authors: Bibee, Kristin P., Cheng, Ya-Jian, Ching, James K., Marsh, Jon N., Li, Allison J., Keeling, Richard M., Connolly, Anne M., Golumbek, Paul T., Myerson, Jacob W., Hu, Grace, Chen, Junjie, Shannon, William D., Lanza, Gregory M., Weihl, Conrad C., Wickline, Samuel A.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2014
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986846/
https://ncbi.nlm.nih.gov/pubmed/24500923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-237388
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