Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function

Duchenne muscular dystrophy in boys progresses rapidly to severe impairment of muscle function and death in the second or third decade of life. Current supportive therapy with corticosteroids results in a modest increase in strength as a consequence of a general reduction in inflammation, albeit wit...

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Detalhes bibliográficos
Main Authors: Bibee, Kristin P., Cheng, Ya-Jian, Ching, James K., Marsh, Jon N., Li, Allison J., Keeling, Richard M., Connolly, Anne M., Golumbek, Paul T., Myerson, Jacob W., Hu, Grace, Chen, Junjie, Shannon, William D., Lanza, Gregory M., Weihl, Conrad C., Wickline, Samuel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986846/
https://ncbi.nlm.nih.gov/pubmed/24500923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-237388
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