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Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy
Pathological phenotypes in inclusion body myopathy (IBM) associated with Paget disease of the bone (PDB), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (IBMPFD/ALS) include defective autophagosome and endosome maturation that result in vacuolation, weakness and muscle atrophy...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3669194/ https://ncbi.nlm.nih.gov/pubmed/23439279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.23958 |
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