JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy

Deficiency or mutation in the p53 tumor suppressor gene commonly occurs in human cancer and can contribute to disease progression and chemotherapy resistance. Currently, although the pro-survival or pro-death effect of autophagy remains a controversial issue, increasing data seem to support the idea...

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Autori principali: Sui, Xinbing, Kong, Na, Wang, Xian, Fang, Yong, Hu, Xiaotong, Xu, Yinghua, Chen, Wei, Wang, Kaifeng, Li, Da, Jin, Wei, Lou, Fang, Zheng, Yu, Hu, Hong, Gong, Liu, Zhou, Xiaoyun, Pan, Hongming, Han, Weidong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986705/
https://ncbi.nlm.nih.gov/pubmed/24733045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04694
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