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Comparison of somatic mutation calling methods in amplicon and whole exome sequence data

BACKGROUND: High-throughput sequencing is rapidly becoming common practice in clinical diagnosis and cancer research. Many algorithms have been developed for somatic single nucleotide variant (SNV) detection in matched tumor-normal DNA sequencing. Although numerous studies have compared the performa...

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Detalhes bibliográficos
Main Authors: Xu, Huilei, DiCarlo, John, Satya, Ravi Vijaya, Peng, Quan, Wang, Yexun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986649/
https://ncbi.nlm.nih.gov/pubmed/24678773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-244
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