Reduced Virulence of an Extensively Drug-Resistant Outbreak Strain of Mycobacterium tuberculosis in a Murine Model

Bacterial drug resistance is often associated with a fitness cost. Large outbreaks of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB have been described that predominately affect persons with HIV infection. We obtained four closely-related Mycobacterium tuberculosis strains (genot...

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Bibliographic Details
Main Authors: Smith, Kristen L. Jurcic, Saini, Divey, Bardarov, Svetoslav, Larsen, Michelle, Frothingham, Richard, Gandhi, Neel R., Jacobs Jr., William R., Sturm, A. Willem, Lee, Sunhee
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986381/
https://ncbi.nlm.nih.gov/pubmed/24733050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094953
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