Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates

The enzymes PhnY and PhnZ comprise an oxidative catabolic pathway that enables marine bacteria to use 2-aminoethylphosphonic acid as a source of inorganic phosphate. PhnZ is notable for catalyzing the oxidative cleavage of a carbon–phosphorus bond using Fe(II) and dioxygen, despite belonging to a la...

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Hauptverfasser: van Staalduinen, Laura M., McSorley, Fern R., Schiessl, Katharina, Séguin, Jacqueline, Wyatt, Peter B., Hammerschmidt, Friedrich, Zechel, David L., Jia, Zongchao
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986159/
https://ncbi.nlm.nih.gov/pubmed/24706911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320039111
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