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Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation

Whereas the protein kinases GCN2, HRI, PKR, and PERK specifically phosphorylate eukaryotic translation initiation factor 2 (eIF2α) on Ser51 to regulate global and gene-specific mRNA translation, eIF2α is dephosphorylated by the broadly acting serine/threonine protein phosphatase 1 (PP1). In mammalia...

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Bibliografiske detaljer
Main Authors: Rojas, Margarito, Gingras, Anne-Claude, Dever, Thomas E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986135/
https://ncbi.nlm.nih.gov/pubmed/24706853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400129111
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