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Distinct Pathways Regulated by RET and Estrogen Receptor in Luminal Breast Cancer Demonstrate the Biological Basis for Combination Therapy

OBJECTIVES: We investigated directed therapy based on TFAP2C-regulated pathways to inform new therapeutic approaches for treatment of luminal breast cancer. BACKGROUND: TFAP2C regulates the expression of genes characterizing the luminal phenotype including ESR1 and RET, but pathway cross talk and po...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Spanheimer, Philip M., Cyr, Anthony R., Gillum, Matthew P., Woodfield, George W., Askeland, Ryan W., Weigel, Ronald J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986044/
https://ncbi.nlm.nih.gov/pubmed/24045439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0b013e3182a6f552
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