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Extension and Limits of the Network of Coupled Motions Correlated to Hydride Transfer in Dihydrofolate Reductase

[Image: see text] Enzyme catalysis has been studied extensively, but the role of enzyme dynamics in the catalyzed chemical conversion is still an enigma. The enzyme dihydrofolate reductase (DHFR) is often used as a model system to assess a network of coupled motions across the protein that may affec...

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Bibliografske podrobnosti
Main Authors: Singh, Priyanka, Sen, Arundhuti, Francis, Kevin, Kohen, Amnon
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985941/
https://ncbi.nlm.nih.gov/pubmed/24450297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja411998h
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