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Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway
[Image: see text] Fumagillin (1), a meroterpenoid from Aspergillus fumigatus, is known for its antiangiogenic activity due to binding to human methionine aminopeptidase 2. 1 has a highly oxygenated structure containing a penta-substituted cyclohexane that is generated by oxidative cleavage of the bi...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Chemical
Society
2014
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985917/ https://ncbi.nlm.nih.gov/pubmed/24568283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja500881e |
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