Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway

[Image: see text] Fumagillin (1), a meroterpenoid from Aspergillus fumigatus, is known for its antiangiogenic activity due to binding to human methionine aminopeptidase 2. 1 has a highly oxygenated structure containing a penta-substituted cyclohexane that is generated by oxidative cleavage of the bi...

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Detalhes bibliográficos
Main Authors: Lin, Hsiao-Ching, Tsunematsu, Yuta, Dhingra, Sourabh, Xu, Wei, Fukutomi, Manami, Chooi, Yit-Heng, Cane, David E., Calvo, Ana M., Watanabe, Kenji, Tang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985917/
https://ncbi.nlm.nih.gov/pubmed/24568283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja500881e
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