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The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene

Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability of the A. fumigatus genome sequence. Here, we r...

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Detaylı Bibliyografya
Asıl Yazarlar: Lin, Hsiao-Ching, Chooi, Yit-Heng, Dhingra, Sourabh, Xu, Wei, Calvo, Ana M., Tang, Yi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652892/
https://ncbi.nlm.nih.gov/pubmed/23488861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja312503y
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