Unexpected Hydrolytic Instability of N-Acylated Amino Acid Amides and Peptides

[Image: see text] Remote amide bonds in simple N-acyl amino acid amide or peptide derivatives 1 can be surprisingly unstable hydrolytically, affording, in solution, variable amounts of 3 under mild acidic conditions, such as trifluoroacetic acid/water mixtures at room temperature. This observation h...

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Detalhes bibliográficos
Main Authors: Samaritoni, J. Geno, Copes, Alexus T., Crews, DeMarcus K., Glos, Courtney, Thompson, Andre L., Wilson, Corydon, O’Donnell, Martin J., Scott, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985854/
https://ncbi.nlm.nih.gov/pubmed/24617596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo500273f
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