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Synthesis of Amino-ADT Provides Access to Hydrolytically Stable Amide-Coupled Hydrogen Sulfide Releasing Drug Targets

As additional physiological functions of hydrogen sulfide (H(2)S) are discovered, developing practical methods for exogenous H(2)S delivery is important. In particular, nonsteroidal anti-inflammatory drugs (NSAIDs) functionalized with H(2)S-releasing anethole dithiolethione (ADT-OH) through ester bo...

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Detalhes bibliográficos
Publicado no:Synlett
Main Authors: Hammers, Matthew D., Singh, Loveprit, Montoya, Leticia A., Moghaddam, Alan D., Pluth, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936786/
https://ncbi.nlm.nih.gov/pubmed/27397970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0035-1560603
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