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Molecular Recognition of Fluorine Impacts Substrate Selectivity in the Fluoroacetyl-CoA Thioesterase FlK

[Image: see text] The fluoroacetate-producing bacterium Streptomyces cattleya has evolved a fluoroacetyl-CoA thioesterase (FlK) that exhibits a remarkably high level of discrimination for its cognate substrate compared to the cellularly abundant analogue acetyl-CoA, which differs only by the absence...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Weeks, Amy M., Keddie, Neil S., Wadoux, Rudy D. P., O’Hagan, David, Chang, Michelle C. Y.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2014
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985765/
https://ncbi.nlm.nih.gov/pubmed/24635371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4015049
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