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Aggregation Gatekeeper and Controlled Assembly of Trpzip β-Hairpins

[Image: see text] Protein and peptide aggregation is an important issue both in vivo and in vitro. Herein, we examine the aggregation behaviors of two well-studied β-hairpins, Trpzip1 and Trpzip2. Previous studies suggested that Trpzip2 remains monomeric up to a concentration of ∼15 mM whereas Trpzi...

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Main Authors: Markiewicz, Beatrice N., Oyola, Rolando, Du, Deguo, Gai, Feng
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985754/
https://ncbi.nlm.nih.gov/pubmed/24498924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401568a
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