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S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection
Insertional oncogene activation and aberrant splicing have proved to be major setbacks for retroviral stem cell gene therapy. Integrase-deficient human immunodeficiency virus-1-derived vectors provide a potentially safer approach, but their circular genomes are rapidly lost during cell division. Her...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985655/ https://ncbi.nlm.nih.gov/pubmed/24474068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku082 |
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