Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A

Rev3, the catalytic subunit of DNA polymerase ζ, is essential for translesion synthesis of cytotoxic DNA photolesions, whereas the Rev1 protein plays a noncatalytic role in translesion synthesis. Here, we reveal that mammalian Rev3(−/−) and Rev1(−/−) cell lines additionally display a nucleotide exci...

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Bibliografiske detaljer
Main Authors: Tsaalbi-Shtylik, Anastasia, Moser, Jill, Mullenders, Leon H. F., Jansen, Jacob G., de Wind, Niels
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985633/
https://ncbi.nlm.nih.gov/pubmed/24464993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1412
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