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Characterization and Engineering of the Adenylation Domain of a NRPS-Like Protein: A Potential Biocatalyst for Aldehyde Generation
[Image: see text] The adenylation (A) domain acts as the first “gate-keeper” to ensure the activation and thioesterification of the correct monomer to nonribosomal peptide synthetases (NRPSs). Our understanding of the specificity-conferring code and our ability to engineer A domains are critical for...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985451/ https://ncbi.nlm.nih.gov/pubmed/24804152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cs500039v |
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