The Chemical Decomposition of 5-aza-2′-deoxycytidine (Decitabine): Kinetic Analyses and Identification of Products by NMR, HPLC, and Mass Spectrometry

The nucleoside analog 5-aza-2′-deoxycytidine (Decitabine, DAC) is one of several drugs in clinical use that inhibit DNA methyltransferases, leading to a decrease of 5-methylcytosine in newly replicated DNA and subsequent transcriptional activation of genes silenced by cytosine methylation. In additi...

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Hlavní autoři: Rogstad, Daniel K., Herring, Jason L., Theruvathu, Jacob A., Burdzy, Artur, Perry, Christopher C., Neidigh, Jonathan W., Sowers, Lawrence C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985229/
https://ncbi.nlm.nih.gov/pubmed/19480391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900131u
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