Structural Determinants of Water Permeation through the Sodium-Galactose Transporter vSGLT

Sodium-glucose transporters (SGLTs) facilitate the movement of water across the cell membrane, playing a central role in cellular homeostasis. Here, we present a detailed analysis of the mechanism of water permeation through the inward-facing state of vSGLT based on nearly 10 μs of molecular dynamic...

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Detalhes bibliográficos
Main Authors: Adelman, Joshua L., Sheng, Ying, Choe, Seungho, Abramson, Jeff, Wright, Ernest M., Rosenberg, John M., Grabe, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984995/
https://ncbi.nlm.nih.gov/pubmed/24655503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.01.006
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