Side-Chain to Main-Chain Hydrogen Bonding Controls the Intrinsic Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix

Many transmembrane helices contain serine and/or threonine residues whose side chains form intrahelical H-bonds with upstream carbonyl oxygens. Here, we investigated the impact of threonine side-chain/main-chain backbonding on the backbone dynamics of the amyloid precursor protein transmembrane heli...

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Main Authors: Scharnagl, Christina, Pester, Oxana, Hornburg, Philipp, Hornburg, Daniel, Götz, Alexander, Langosch, Dieter
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2014
Assuntos:
Membranes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984980/
https://ncbi.nlm.nih.gov/pubmed/24655507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.02.013
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