Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis

Hematopoietic stem cells (HSCs) are produced by a small cohort of hemogenic endothelial cells (ECs) during development through the formation of intra-aortic hematopoietic cell (HC) clusters (HCs). The Runx1 transcription factor plays a key role in the EC to HC and HSC transition. We show that Runx1...

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Main Authors: Richard, Charlotte, Drevon, Cécile, Canto, Pierre-Yves, Villain, Gaelle, Bollérot, Karine, Lempereur, Aveline, Teillet, Marie-Aimée, Vincent, Christine, Castillo, Catalina Rosselló, Torres, Miguel, Piwarzyk, Eileen, Speck, Nancy A., Souyri, Michèle, Jaffredo, Thierry
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984929/
https://ncbi.nlm.nih.gov/pubmed/23537631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.02.011
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