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Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
Recent studies have propagated the model that the mitochondrial unfolded protein response (UPR(mt)) is causal for lifespan extension from inhibition of the electron transport chain (ETC) in C. elegans. Here we report a genome-wide RNAi screen for negative regulators of the UPR(mt). Lifespan analysis...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984390/ https://ncbi.nlm.nih.gov/pubmed/24662282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4483 |
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