Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer

BACKGROUND: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. METHODS: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their associ...

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Главные авторы: Sanoff, Hanna K., Renfro, Lindsay A., Poonnen, Pradeep, Ambadwar, Pratibha, Sargent, Daniel J., Goldberg, Richard M., McLeod, Howard
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984266/
https://ncbi.nlm.nih.gov/pubmed/24727911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094727
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