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Impaired pancreatic growth, β cell mass, and β cell function in E2F1 (–/– )mice
We evaluated the effects of E2F1 on glucose homeostasis using E2F1(–/–) mice. E2F1(–/–) mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth. Furthermore, these animals have dysfunctional β cells, linked to impaired PDX-1 activity. Because of the di...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC398423/ https://ncbi.nlm.nih.gov/pubmed/15124020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418555 |
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