Striatal Synaptic Dysfunction and Hippocampal Plasticity Deficits in the Hu97/18 Mouse Model of Huntington Disease

Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the gene (HTT) encoding the huntingtin protein (HTT). This mutation leads to multiple cellular and synaptic alterations that are mimicked in many current HD animal models. However, the most commonly use...

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Bibliographic Details
Main Authors: Kolodziejczyk, Karolina, Parsons, Matthew P., Southwell, Amber L., Hayden, Michael R., Raymond, Lynn A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984157/
https://ncbi.nlm.nih.gov/pubmed/24728353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094562
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