Histone Deacetylase Inhibitors Sensitize Lung Cancer Cells to Hyperthermia: Involvement of Ku70/SirT-1 in Thermo-Protection

This study describes the sensitization mechanism to thermal stress by histone deacetylase inhibitors (HDACIs) in lung cancer cells and shows that Ku70, based on its acetylation status, mediates the protection of lung cancer from hyperthermia (42.5°C, 1-6 hrs). Ku70 regulates apoptosis by sequesterin...

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Autori principali: Hassan, Mohamed K., Watari, Hidemichi, Salah-eldin, Alaa-eldin, Sultan, Ahmed S., Mohamed, Zainab, Fujioka, Yoichiro, Ohba, Yusuke, Sakuragi, Noriaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984116/
https://ncbi.nlm.nih.gov/pubmed/24728004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094213
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