Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

In mammals, many cytokines and growth factors stimulate members of the Janus kinase (JAK) family to transduce signals for the proliferation and differentiation of various cell types, particularly in hematopoietic lineages. Mutations in the Drosophila hopscotch (hop) gene, which encodes a JAK, also c...

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Udgivet i:EMBO J
Main Authors: Harrison, D A, Binari, R, Nahreini, T S, Gilman, M, Perrimon, N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398404/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7796812/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07285.x
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