Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.

Furin, a subtilisin-like eukaryotic endoprotease, is responsible for proteolytic cleavage of cellular and viral proteins transported via the constitutive secretory pathway. Cleavage occurs at the C-terminus of basic amino acid sequences, such as R-X-K/R-R and R-X-X-R. Furin was found predominantly i...

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Autors principals: Schäfer, W, Stroh, A, Berghöfer, S, Seiler, J, Vey, M, Kruse, M L, Kern, H F, Klenk, H D, Garten, W
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC398356/
https://ncbi.nlm.nih.gov/pubmed/7781597
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