B1 Cells Promote Pancreas Infiltration by Autoreactive T Cells

The entry of autoreactive T cells into the pancreas is a critical checkpoint in the development of autoimmune diabetes. In this study, we identify a role for B1 cells in this process using the DO11 × RIP-mOVA mouse model. In transgenic mice with islet-specific T cells, but no B cells, T cells are pr...

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Main Authors: Ryan, Gemma A., Wang, Chun Jing, Chamberlain, Jayne L., Attridge, Kesley, Schmidt, Emily M., Kenefeck, Rupert, Clough, Louise E., Dunussi-Joannopoulos, Kyri, Toellner, Kai-Michael, Walker, Lucy S. K.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983558/
https://ncbi.nlm.nih.gov/pubmed/20675587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000856
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