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Can Amphipathic Helices Influence the CNS Antinociceptive Activity of Glycopeptides Related to β-Endorphin?
[Image: see text] Glycosylated β-endorphin analogues of various amphipathicity were studied in vitro and in vivo in mice. Opioid binding affinities of the O-linked glycopeptides (mono- or disaccharides) and unglycosylated peptide controls were measured in human receptors expressed in CHO cells. All...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983389/ https://ncbi.nlm.nih.gov/pubmed/24576160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400879w |
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