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Mutagenesis Studies of the 14 Å Internal Cavity of Histone Deacetylase 1: Insights toward the Acetate-Escape Hypothesis and Selective Inhibitor Design

[Image: see text] Histone deacetylase (HDAC) proteins are promising targets for cancer treatment, as shown by the approval of two HDAC inhibitors for the treatment of cutaneous T-cell lymphoma. HDAC1 in particular has been linked to cell growth and cell cycle regulation and is therefore an attractiv...

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Detalhes bibliográficos
Main Authors: Wambua, Magdalene K., Nalawansha, Dhanusha A., Negmeldin, Ahmed T., Pflum, Mary Kay H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983352/
https://ncbi.nlm.nih.gov/pubmed/24405391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401837e
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