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Asymmetric Synthesis of α-Allyl-α-Aryl α-Amino Acids by Tandem Alkylation/π-Allylation of α-Iminoesters

[Image: see text] The first asymmetric synthesis of α-allyl-α-aryl α-amino acids by means of a three-component coupling of α-iminoesters, Grignard reagents, and cinnamyl acetate is reported. Notably, the enolate from the tandem process provides a much higher level of reactivity and selectivity than...

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Bibliographic Details
Main Authors: Curto, John M., Dickstein, Joshua S., Berritt, Simon, Kozlowski, Marisa C.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983326/
https://ncbi.nlm.nih.gov/pubmed/24666394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol500506t
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