GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

The TGF-beta type II receptor (T beta R-II) is a transmembrane serine/threonine kinase that, upon ligand binding, recruits and phosphorylates a second transmembrane kinase, T beta R-I, as a requirement for signal transduction. T beta R-I is phosphorylated by T beta R-II in the GS domain, a 30 amino...

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Pubblicato in:	EMBO J
Autori principali:	Wieser, R, Wrana, J L, Massagué, J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398326/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7774578/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07214.x
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