Biophysical Properties of Intrinsically Disordered p130Cas Substrate Domain — Implication in Mechanosensing

Mechanical stretch-induced tyrosine phosphorylation in the proline-rich 306-residue substrate domain (CasSD) of p130Cas (or BCAR1) has eluded an experimentally validated structural understanding. Cellular p130Cas tyrosine phosphorylation is shown to function in areas without internal actomyosin cont...

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Bibliographische Detailangaben
Hauptverfasser: Hotta, Kinya, Ranganathan, Soumya, Liu, Ruchuan, Wu, Fei, Machiyama, Hiroaki, Gao, Rong, Hirata, Hiroaki, Soni, Neelesh, Ohe, Takashi, Hogue, Christopher W. V., Madhusudhan, M. S., Sawada, Yasuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983058/
https://ncbi.nlm.nih.gov/pubmed/24722239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003532
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