Combination Therapy With Lysin CF-301 and Antibiotic Is Superior to Antibiotic Alone for Treating Methicillin-Resistant Staphylococcus aureus–Induced Murine Bacteremia

Lysins are bacteriophage-derived enzymes that degrade bacterial peptidoglycans. Lysin CF-301 is being developed to treat Staphylococcus aureus because of its potent, specific, and rapid bacteriolytic effects. It also demonstrates activity on drug-resistant strains, has a low resistance profile, erad...

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Bibliographische Detailangaben
Hauptverfasser: Schuch, Raymond, Lee, Han M., Schneider, Brent C., Sauve, Karen L., Law, Christina, Khan, Babar K., Rotolo, Jimmy A., Horiuchi, Yuki, Couto, Daniel E., Raz, Assaf, Fischetti, Vincent A., Huang, David B., Nowinski, Robert C., Wittekind, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982849/
https://ncbi.nlm.nih.gov/pubmed/24286983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit637
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