An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution

Background. Typhoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella Typhi infection. Until 1974, a human challenge model advanced understanding of typhoid and was used in vaccine development. We set out to estab...

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Main Authors: Waddington, Claire S., Darton, Thomas C., Jones, Claire, Haworth, Kathryn, Peters, Anna, John, Tessa, Thompson, Ben A. V., Kerridge, Simon A., Kingsley, Robert A., Zhou, Liqing, Holt, Kathryn E., Yu, Ly-Mee, Lockhart, Stephen, Farrar, Jeremy J., Sztein, Marcelo B., Dougan, Gordon, Angus, Brian, Levine, Myron M., Pollard, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Articles and Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982839/
https://ncbi.nlm.nih.gov/pubmed/24519873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciu078
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