WIDE AWAKE Mediates the Circadian Timing of Sleep Onset

How the circadian clock regulates the timing of sleep is poorly understood. Here, we identify a Drosophila mutant, wide awake (wake), that exhibits a marked delay in sleep onset at dusk. Loss of WAKE in a set of arousal-promoting clock neurons, the large ventrolateral neurons (l-LNvs), impairs sleep...

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Detalhes bibliográficos
Main Authors: Liu, Sha, Lamaze, Angelique, Liu, Qili, Tabuchi, Masashi, Yang, Yong, Fowler, Melissa, Bharadwaj, Rajnish, Zhang, Julia, Bedont, Joseph, Blackshaw, Seth, Lloyd, Thomas E., Montell, Craig, Sehgal, Amita, Koh, Kyunghee, Wu, Mark N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982794/
https://ncbi.nlm.nih.gov/pubmed/24631345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.01.040
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