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Lead optimization of HMBA to develop potent HEXIM1 inducers

The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives inducing Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in LNCaP prostate cancer cells. Several compounds with unsymmetrical structures showed significantly improved activity. Distinct from HMBA, these...

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Detalhes bibliográficos
Main Authors: Zhong, Bo, Lama, Rati, Ketchart, Wannarasmi, Montano, Monica M., Su, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982598/
https://ncbi.nlm.nih.gov/pubmed/24503105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.01.025
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