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Lead optimization of HMBA to develop potent HEXIM1 inducers
The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives inducing Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in LNCaP prostate cancer cells. Several compounds with unsymmetrical structures showed significantly improved activity. Distinct from HMBA, these...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3982598/ https://ncbi.nlm.nih.gov/pubmed/24503105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.01.025 |
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