Increased Burden of Cardiovascular Disease in Carriers of APOL1 Genetic Variants

RATIONALE: Two distinct alleles in the gene encoding apolipoprotein L1 (APOL1), a major component of HDL, confer protection against Trypanosoma brucei rhodesiense infection and also increase risk for chronic kidney disease (CKD). Approximately 14% of African-Americans carry two APOL1 risk alleles, a...

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Main Authors: Ito, Kaoru, Bick, Alexander G., Flannick, Jason, Friedman, David J., Genovese, Giulio, Parfenov, Michael G., DePalma, Steven R., Gupta, Namrata, Gabriel, Stacey B., Taylor, Herman A., Fox, Ervin R., Newton-Cheh, Christopher, Kathiresan, Sekar, Hirschhorn, Joel N., Altshuler, David M., Pollak, Martin R., Wilson, James G., Seidman, J. G., Seidman, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982584/
https://ncbi.nlm.nih.gov/pubmed/24379297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302347
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