Chemical reconstitution of a chloride pump inactivated by a single point mutation.

The arginine residue R108 plays an essential role in the transport mechanism of the light-driven anion pump halorhodopsin (HR) as demonstrated by complete inactivation of chloride transport in mutant HR-R108Q. In the presence of substrate anions, guanidinium ions bind to the mutant protein with affi...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Rüdiger, M, Haupts, U, Gerwert, K, Oesterhelt, D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398252/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7737112/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07148.x
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