Targeting the Splicing of mRNA in Autoimmune Diseases: BAFF Inhibition in Sjögren's Syndrome as a Proof of Concept

BAFF (B-cell–activating factor of the tumor necrosis factor family), a pivotal cytokine for B-cell activation, is overexpressed by salivary gland (SG) epithelial cells in primary Sjogren's syndrome (pSS). ΔBAFF, a physiological inhibitor of BAFF, is a minor alternative splice variant of BAFF. A...

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Main Authors: Roescher, N., Vosters, J.L., Alsaleh, G., Dreyfus, P., Jacques, S., Chiocchia, G., Sibilia, J., Tak, P.P., Chiorini, J.A., Mariette, X., Gottenberg, Jacques-Eric
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982500/
https://ncbi.nlm.nih.gov/pubmed/24304965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.275
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