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Direct Renin Inhibition Prevents Cardiac Dysfunction in a Diabetic Mouse Model: Comparison with an Angiotensin Receptor Antagonist and Angiotensin Converting Enzyme Inhibitor

Hyperglycemia upregulates intracellular angiotensin II production in cardiac myocytes, effects of which are blocked more effectively by renin inhibition than angiotensin receptor blockers (ARBs) or ACE inhibitors. Here we determined whether renin inhibition is more effective at preventing diabetic c...

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Detalhes bibliográficos
Main Authors: Thomas, Candice M., Yong, Qian Chen, Seqqat, Rachid, Chandel, Niketa, Feldman, David L., Baker, Kenneth M., Kumar, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982397/
https://ncbi.nlm.nih.gov/pubmed/23116220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20120448
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